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Tuesday, 27 December 2011
Genetics Faculty Candidate Seminar, Giovanni Bosco, Associate Professor of Molecular and Cellular Biology, University of Arizona
Monday, 26 December 2011
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Sunday, 25 December 2011
UK News: Charity hails East Africa appeal
Dec 26 2011
Save the Children said its East Africa emergency appeal has become the most successful in the charity's history after Britons donated more than ?7 million in six months.
The appeal, which was launched in July, has surpassed the previous record of ?6.8 million raised for Asian tsunami victims.
Save the Children's chief executive Justin Forsyth said the money was spent on providing food, clean water and healthcare to 1.7 million children affected by the drought in East Africa.
"Even when times are tough at home, this shows that British people care deeply about the world's most vulnerable children," Mr Forsyth said.
"They know that their help - however small - can be the difference between life and death for children facing unimaginable suffering."
One such child is Umi, a baby girl found by Save the Children outreach staff in a remote village in rural Kenya. Mr Forsyth said Umi had life-threatening malnutrition but made a full recovery after the charity intervened.
But he said the scale of the food crisis was enormous and thousands of other children, particularly in Somalia, urgently needed help.
An estimated 250,000 people are in urgent need of assistance in Somalia, he said, just days after International Development Secretary Andrew Mitchell announced Britain was providing more than 9,000 tonnes of food supplies and medicines to drought-ravaged regions in the Horn of Africa.
Mr Mitchell told BBC Radio 4's Today programme that Somalia was a direct threat to the UK's security because it was one of the "most dysfunctional countries in the world". He said aid made "the difference between life and death" as millions across the region "face a fight for life".
The Government will host a conference on Somalia in London on February 23, Prime Minister David Cameron announced last month. Mr Cameron said Somalia was a failed state during a speech at the Lord Mayor's banquet on November 14.
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Breast Cancer Patients Face More Imaging Tests Today - iVillage
FRIDAY, Dec. 23 (HealthDay News) -- Women with breast cancer undergo many more imaging tests between diagnosis and surgery than they did in the early 1990s, a new study finds.
The tests -- breast ultrasounds, MRIs and mammograms -- help doctors determine the best course of treatment, but add to the hassles and expense of care, the study says.
"The burden to the patient is increasing substantially," said study leader Dr. Richard Bleicher, an associate professor of surgical oncology at Fox Chase Cancer Center in Philadelphia. For older patients, especially, coordination of care is needed, he said.
Bleicher, a breast surgeon, evaluated data on more than 67,000 women in the United States diagnosed with breast cancer from 1992 to 2005. His intent was to clock the time and inconvenience involved in multiple imaging appointments.
In 1992, he found that 1 in 20, or under 5 percent of patients, had imaging twice or more during the preoperative period of about 37 days. By 2005, 1 in 5 patients, or nearly 20 percent, had two or more imaging sessions.
"Patients are having a lot more imaging done overall," he said. "I can't tell you whether the imaging was appropriate or not appropriate."
The percentage of patients who had more than one type of imaging on a given day increased more than six-fold, from about 4 percent in 1992 to just over 27 percent in 2005, the study found.
A subgroup of 20 patients had five or more mammogram visits during the pre-op period, he found.
For the study, the researchers used Medicare claims linked to the U.S. National Cancer Institute's Surveillance Epidemiology End Results data for women with breast cancer. They zeroed in on about 67,750 women over age 65 who had invasive cancer that hadn't spread and who were scheduled for surgery.
Bleicher presented the findings earlier this month at the San Antonio Breast Cancer Symposium. He urged his colleagues to consider ways of streamlining the testing, with an eye to improving treatment without raising costs.
The increase in imaging tests does not surprise Dr. Carol Lee, head of the communications committee for the American College of Radiology Breast Imaging Commission.
"Practices have changed," she said. "Standards of care have changed." Since 1992, imaging technology has advanced greatly, she said, noting there are more, and better, options.
One limitation of the study, she said, is that the outcomes are not addressed. "This is not telling the whole story," she said. "What gets lost in the numbers is, what are the possible benefits of this additional imaging?"
"Yes, we are doing more tests," she said. "But we are not doing tests for the sake of doing tests."
Some states have laws that address self-referral, said Shawn Farley, spokesperson for the American College of Radiology. The specifics of the laws vary.
Lee agreed with Bleicher that doctors should strive for better coordination of imaging tests.
If your doctor orders imaging, Bleicher recommends asking why it's needed. You might also ask if the doctor expects more imaging will be needed and if so, whether it's possible to schedule tests together, he said.
The study was supported by the U.S. Public Health Service, the American Cancer Society, the Commonwealth of Pennsylvania and private donors.
Research presented at meetings should be considered preliminary until published in a peer-reviewed medical journal.
More information
For more on breast cancer imaging, see the American College of Radiology patient information page.
Source: http://www.ivillage.com/breast-cancer-patients-face-more-imaging-tests-today/4-a-413524
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FCC approves AT&T's $1.9b purchase of Qualcomm's 700MHz spectrum (update)
Christmas has come early to the execs at AT&T, who are likely celebrating the FCC's 3-1 approval to purchase Qualcomm's block of the 700MHz spectrum for $1.9 billion. The news comes as a bittersweet victory for Ma Bell, whose efforts to acquire T-Mobile turned sour earlier this year. Qualcomm's block of the airwaves, once used to facilitate FLO TV, now sits unused. Once the acquisition is complete, AT&T will use the new share of spectrum to increase download capacity for its burgeoning LTE network.
For the FCC's part, it has approved the deal with only a few stipulations: AT&T will be required to satisfy interference requirements and must offer data roaming to its competitors on the spectrum. That's not to suggest everyone's pleased, however. Rural cellular providers asked that, as part of the deal, AT&T must ensure that its LTE network is interoperable with the bands used by smaller networks. Sadly, the FCC has denied this request, ostensibly limiting the little guy from receiving Ma Bell's hand-me-downs.
Update: AT&T has gone ahead and released a wee bit of celebratory PR, which we're including after the break. Most importantly, it expects to wrap up the finer details in the next few days.
For the FCC's part, it has approved the deal with only a few stipulations: AT&T will be required to satisfy interference requirements and must offer data roaming to its competitors on the spectrum. That's not to suggest everyone's pleased, however. Rural cellular providers asked that, as part of the deal, AT&T must ensure that its LTE network is interoperable with the bands used by smaller networks. Sadly, the FCC has denied this request, ostensibly limiting the little guy from receiving Ma Bell's hand-me-downs.
Update: AT&T has gone ahead and released a wee bit of celebratory PR, which we're including after the break. Most importantly, it expects to wrap up the finer details in the next few days.
Continue reading FCC approves AT&T's $1.9b purchase of Qualcomm's 700MHz spectrum (update)
FCC approves AT&T's $1.9b purchase of Qualcomm's 700MHz spectrum (update) originally appeared on Engadget on Thu, 22 Dec 2011 21:20:00 EDT. Please see our terms for use of feeds.
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Three U.S. citizens killed in Mexico attacks (Reuters)
MEXICO CITY (Reuters) ? Three U.S. citizens were among those killed when gunmen attacked buses in the eastern Mexican state of Veracruz, said a U.S. State Department official said on Saturday.
The three were traveling for the holidays when they and several other passengers on the bus were killed by gunmen on Thursday, according to the U.S. official and local media.
The incident was one of several that day in which gunmen attacked busses in the eastern state, a major oil export hub that has lately become a flashpoint for drug gang violence.
On Friday, the tortured bodies of 10 people were found in northern Veracruz, local media reported, as attacks in the region intensify between the Zetas gang and Gulf drug cartels.
In September, 35 bodies were dumped along a downtown highway in the Veracruz city of Boca del Rio.
More than 45,000 people have been killed in cartel-related violence since President Felipe Calderon took office in December 2006.
(Reporting by Patrick Rucker)
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Saturday, 24 December 2011
Breast Cancer Patients Face More Imaging Tests Today (HealthDay)
FRIDAY, Dec. 23 (HealthDay News) -- Women with breast cancer undergo many more imaging tests between diagnosis and surgery than they did in the early 1990s, a new study finds.
The tests -- breast ultrasounds, MRIs and mammograms -- help doctors determine the best course of treatment, but add to the hassles and expense of care, the study says.
"The burden to the patient is increasing substantially," said study leader Dr. Richard Bleicher, an associate professor of surgical oncology at Fox Chase Cancer Center in Philadelphia. For older patients, especially, coordination of care is needed, he said.
Bleicher, a breast surgeon, evaluated data on more than 67,000 women in the United States diagnosed with breast cancer from 1992 to 2005. His intent was to clock the time and inconvenience involved in multiple imaging appointments.
In 1992, he found that 1 in 20, or under 5 percent of patients, had imaging twice or more during the preoperative period of about 37 days. By 2005, 1 in 5 patients, or nearly 20 percent, had two or more imaging sessions.
"Patients are having a lot more imaging done overall," he said. "I can't tell you whether the imaging was appropriate or not appropriate."
The percentage of patients who had more than one type of imaging on a given day increased more than six-fold, from about 4 percent in 1992 to just over 27 percent in 2005, the study found.
A subgroup of 20 patients had five or more mammogram visits during the pre-op period, he found.
For the study, the researchers used Medicare claims linked to the U.S. National Cancer Institute's Surveillance Epidemiology End Results data for women with breast cancer. They zeroed in on about 67,750 women over age 65 who had invasive cancer that hadn't spread and who were scheduled for surgery.
Bleicher presented the findings earlier this month at the San Antonio Breast Cancer Symposium. He urged his colleagues to consider ways of streamlining the testing, with an eye to improving treatment without raising costs.
The increase in imaging tests does not surprise Dr. Carol Lee, head of the communications committee for the American College of Radiology Breast Imaging Commission.
"Practices have changed," she said. "Standards of care have changed." Since 1992, imaging technology has advanced greatly, she said, noting there are more, and better, options.
One limitation of the study, she said, is that the outcomes are not addressed. "This is not telling the whole story," she said. "What gets lost in the numbers is, what are the possible benefits of this additional imaging?"
"Yes, we are doing more tests," she said. "But we are not doing tests for the sake of doing tests."
Some states have laws that address self-referral, said Shawn Farley, spokesperson for the American College of Radiology. The specifics of the laws vary.
Lee agreed with Bleicher that doctors should strive for better coordination of imaging tests.
If your doctor orders imaging, Bleicher recommends asking why it's needed. You might also ask if the doctor expects more imaging will be needed and if so, whether it's possible to schedule tests together, he said.
The study was supported by the U.S. Public Health Service, the American Cancer Society, the Commonwealth of Pennsylvania and private donors.
Research presented at meetings should be considered preliminary until published in a peer-reviewed medical journal.
More information
For more on breast cancer imaging, see the American College of Radiology patient information page.
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Wave of Bomb Attacks Kill at Least 60 in Baghdad Following Withdrawal of US Troops
Another Obama success story?
At least 60 people were killed today in 14 bomb attacks in Baghdad following the withdrawal of US troops this week.
Here?s amazing raw footage of one of the major explosions today.
A wave of at least 14 bombings ripped across Baghdad Thursday morning, killing at least 60 people in the worst violence in Iraq for months. The apparently coordinated attacks struck days after the last American forces left the country and in the midst of a major government crisis between Shiite and Sunni politicians that has sent sectarian tensions soaring.
The bombings may be linked more to the U.S. withdrawal than the political crisis, but all together, the developments heighten fears of a new round of Shiite-Sunni sectarian bloodshed like the one a few years back that pushed Iraq to the brink of civil war.
There was no immediate claim of responsibility. But the bombings bore all the hallmarks of al Qaeda?s Sunni insurgents. Most appeared to hit Shiite neighborhoods, although some Sunni areas were also targeted. In all, 11 neighborhoods were hit by either car bombs, roadside blasts or sticky bombs attached to cars. There was at least one suicide bombing and the blasts went off over several hours.
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Source: http://www.liveleak.com/view?i=6c8_1324586030
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Viagra against heart failure: Researchers at the RUB and from Rochester throw light on the mechanism
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 23-Dec-2011[ | E-mail |
Share ] Contact: Professor Dr. Wolfgang Linke
wolfgang.linke@rub.de
49-234-322-9101
Ruhr-University Bochum
Circulation: active ingredient sildenafil makes stiffened cardiac walls elastic again
How sildenafil, the active ingredient in Viagra, can alleviate heart problems is reported by Bochum's researchers in cooperation with colleagues from the Mayo Clinic in Rochester (Minnesota) in the journal Circulation. They studied dogs with diastolic heart failure, a condition in which the heart chamber does not sufficiently fill with blood. The scientists showed that sildenafil makes stiffened cardiac walls more elastic again. The drug activates an enzyme that causes the giant protein titin in the myocardial cells to relax. "We have developed a therapy in an animal model that, for the first time, also raises hopes for the successful treatment of patients" says Prof. Dr. Wolfgang Linke of the RUB Institute of Physiology.
"Rubber band proteins" can be influenced
Sildenafil inhibits a specific enzyme (phosphodiesterase 5 A), which causes the increased formation of a messenger substance (cGMP). The messenger substance activates the enzyme protein kinase G, which attaches phosphate groups to certain proteins. This so-called phosphorylation causes blood vessels to relax, which was why the "potency pill" Viagra originally came onto the market. The Bochum and Rochester researchers found that the cardiac muscle protein titin is also phosphorylated through the same mechanism. "The titin molecules are similar to rubber bands" explains the Bochum physiologist. "They contribute decisively to the stiffness of the cardiac walls." The activity of the protein kinase G causes titin to relax. This makes the cardiac walls more elastic. The effect occurs within minutes of administering the drug.
Heart failure drugs currently not sufficient
"Of all the patients aged over 60 who are in hospital because of a weak heart, half suffer from diastolic heart failure" explains Linke. "Although we know that the decreased distensibility of the cardiac walls is the cause, the disease cannot be treated properly with today's medicines." In the so-called "Relax" study of the Heart Failure Network, the efficacy of sildenafil in people is already being tested. "If, for the first time, the drug is found to have a positive effect on heart failure, we would already have a molecular mechanism on hand to explain the effect" says Linke.
###
Bibliographic record
K. Bishu, N. Hamdani, S.F. Mohammed, M. Kruger, T. Ohtani, O. Ogut, F.V. Brozovich, J.C. Burnett, W.A. Linke, M.M. Redfield (2011): Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo, Circulation, doi: 10.1161/CIRCULATIONAHA.111.048520
Figure online
A figure related to this press release can be found at http://aktuell.ruhr-uni-bochum.de/pm2011/pm00423.html.en
Further information
Prof. Dr. Wolfgang Linke, Department of Cardiovascular Physiology, Institute of Physiology, Medical Faculty of the Ruhr-Universitt, 44780 Bochum, Tel.: +49/234/32-29101 wolfgang.linke@rub.de
Cardiovascular physiology at the RUB
http://www.py.ruhr-uni-bochum.de/kardp/Index.html
"Relax" study
https://www.hfnetwork.org/hf-trials/relax-trial/
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 23-Dec-2011[ | E-mail |
Share ] Contact: Professor Dr. Wolfgang Linke
wolfgang.linke@rub.de
49-234-322-9101
Ruhr-University Bochum
Circulation: active ingredient sildenafil makes stiffened cardiac walls elastic again
How sildenafil, the active ingredient in Viagra, can alleviate heart problems is reported by Bochum's researchers in cooperation with colleagues from the Mayo Clinic in Rochester (Minnesota) in the journal Circulation. They studied dogs with diastolic heart failure, a condition in which the heart chamber does not sufficiently fill with blood. The scientists showed that sildenafil makes stiffened cardiac walls more elastic again. The drug activates an enzyme that causes the giant protein titin in the myocardial cells to relax. "We have developed a therapy in an animal model that, for the first time, also raises hopes for the successful treatment of patients" says Prof. Dr. Wolfgang Linke of the RUB Institute of Physiology.
"Rubber band proteins" can be influenced
Sildenafil inhibits a specific enzyme (phosphodiesterase 5 A), which causes the increased formation of a messenger substance (cGMP). The messenger substance activates the enzyme protein kinase G, which attaches phosphate groups to certain proteins. This so-called phosphorylation causes blood vessels to relax, which was why the "potency pill" Viagra originally came onto the market. The Bochum and Rochester researchers found that the cardiac muscle protein titin is also phosphorylated through the same mechanism. "The titin molecules are similar to rubber bands" explains the Bochum physiologist. "They contribute decisively to the stiffness of the cardiac walls." The activity of the protein kinase G causes titin to relax. This makes the cardiac walls more elastic. The effect occurs within minutes of administering the drug.
Heart failure drugs currently not sufficient
"Of all the patients aged over 60 who are in hospital because of a weak heart, half suffer from diastolic heart failure" explains Linke. "Although we know that the decreased distensibility of the cardiac walls is the cause, the disease cannot be treated properly with today's medicines." In the so-called "Relax" study of the Heart Failure Network, the efficacy of sildenafil in people is already being tested. "If, for the first time, the drug is found to have a positive effect on heart failure, we would already have a molecular mechanism on hand to explain the effect" says Linke.
###
Bibliographic record
K. Bishu, N. Hamdani, S.F. Mohammed, M. Kruger, T. Ohtani, O. Ogut, F.V. Brozovich, J.C. Burnett, W.A. Linke, M.M. Redfield (2011): Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo, Circulation, doi: 10.1161/CIRCULATIONAHA.111.048520
Figure online
A figure related to this press release can be found at http://aktuell.ruhr-uni-bochum.de/pm2011/pm00423.html.en
Further information
Prof. Dr. Wolfgang Linke, Department of Cardiovascular Physiology, Institute of Physiology, Medical Faculty of the Ruhr-Universitt, 44780 Bochum, Tel.: +49/234/32-29101 wolfgang.linke@rub.de
Cardiovascular physiology at the RUB
http://www.py.ruhr-uni-bochum.de/kardp/Index.html
"Relax" study
https://www.hfnetwork.org/hf-trials/relax-trial/
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2011-12/rb-vah122311.php
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Friday, 23 December 2011
Italian Olympic official predicts Canada will win 16 medals at London 2012
Canada will bring home 16 medals from the London Olympics and finish 18th in the medal standings, according to an Italian sports official who projects Games results.
Luciano Barra has Canadians winning five gold, two silver and nine bronze in his medal projections based on recent world championships.
More related to this story
?Canada in London will surely do very well because your program 'Own the Podium' is one of the best in the world,? Barra said in an e-mail to The Canadian Press. ?Still you have to remember that the Summer Games are not like the Winter!?
Still 16 medals would be two less than Canada collected in 2008 in Beijing. The Canadian team won three gold, nine silver and six bronze to finish 19th in the medal standings in China.
Barra, a former senior member of the Italian Olympic Committee, has Canada sandwiched between Hungary in 17th and the Netherlands in 19th in his projected London medal standings.
Barra has China topping the overall and gold medal count with 103 medals ? 43 gold, 31 silver and 29 bronze.
He predicts the U.S. will finish second with 82 medals ? 35 gold, 19 silver and 28 bronze. He has Russia third with 76 overall ? 30, 22 and 24.
Canada won 26 medals at the 2010 Winter Games in Vancouver ? 14 gold, seven silver and five bronze ? to finish third in total medals behind the No. 1 Americans (37) and Germany (30).
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Thursday, 22 December 2011
Carolalong and Golf Cart Parade Info
Ignore the date on this post (in the above header)?
?Blogger has gone crazy.
I posted it a couple of times and I guess that confused the software.
?Blogger has gone crazy.
I posted it a couple of times and I guess that confused the software.
Carolalong & Decorated Golf Cart Parade.
Break out your strings of lights,
?hang some tinsel off your missile toes..
I never even knew missiles had toes!
The house and RV?decorations will be judged 17 - 24.
? Prize for most unique beautiful home or?RV
is a dinner with Robert & Lucie!!!
?Golf cart prize is a surprise!
?(Guess that means they just don't know yet what it will be)
? Both awarded on the 24th at Flip Flopz
after parade and carolalong.?
? For the carolalong (I've been spelling it WRONG AllAlong
on every poster and blog entry!)
Meet at paved area by the pavilion and form a parade.?
?The parade will stop?at any?home who would like a carol.
(Let Karen #434?know if you want us to stop.)
?After visits & the parade libations at Flip Flopz & more singing! Christmas Cheer!!!
Source: http://sandpiperpaper.blogspot.com/2011/12/carolalong-and-golf-cart-parade-info.html
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